[Omeo33] Art 0868 - Homeopathy, 2008, 97 (4), 185-189

[Gino Santini]

Lipid peroxidation, erythrocyte antioxidants and plasma antioxidants 
in osteoarthritis before and after homeopathic treatment
S. Pinto, A.V. Rao and A. Rao

Objective - This study attempts to evaluate the status of oxidative 
stress in osteoarthritis (OA), by measuring some parameters of 
oxidant stress and antioxidant defenses in blood, before and after 
homeopathy treatment, and to asses the role, if any, of homeopathic 
treatment in modulating free radical toxicity in OA.
Methods - Erythrocyte lipid peroxidation (LP), erythrocyte 
antioxidants viz., glutathione (GSH), glutathione reductase (GR), 
superoxide dismutase (SOD), catalase (CT) and plasma antioxidants 
viz., ceruloplasmin, glutathione-S-transferase (GST), vitamin C, 
total antioxidant activity (AOA) were determined in eighty one 
patients with OA and fifty three normals. Forty seven patients, who 
were treated with homeopathic remedies were considered for the 
follow-up studies.
Location - Father Muller Homeopathic Hospital, Mangalore, South 
Karnataka, India.
Results - Erythrocyte LP (0 hour, p < 0.001; 2 hours, p < 0.01; and 
susceptibility to LP, p < 0.05) and SOD (p < 0.05) were significantly 
higher, whereas plasma vitamin C (p < 0.01) and AOA (p < 0.001) were 
significantly lower in OA patients when compared to controls. In 
follow-up patients the erythrocyte LP (0 hour, p < 0.01; 2 hours, p < 
0.01; and susceptibility to LP, p < 0.01) and SOD (p < 0.01) were 
significantly lower when compared to their pretreatment values. 
Plasma vitamin C attained a normal range. The AOA activity after 
treatment was not significantly different from that observed before 
treatment.
Conclusion - Oxidative stress increased in OA as indicated by 
increased LP, SOD, decreased vitamin C and AOA. On homeopathic 
treatment the LP has decreased in the erythrocytes which shows and 
reduced oxidative stress. This is further evidenced by returning of 
plasma vitamin C and erythrocyte SOD to the normal levels, but 
oxidant stress has not been completely overcome as plasma AOA 
remained low after treatment.

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