[Omeo33] Art 0743 - Asian Pac J Cancer Prev, 2007, 8 (1), 98-102

[Gino Santini]

Inhibition of chemically induced carcinogenesis by drugs used in  
homeopathic medicine
Kumar KH, Sunila ES, Kuttan G, Preethi KC, Venugopal CN, Kuttan R.

Homeopathy is considered as one modality for cancer therapy. However,  
there are only very few clinical reports on the activity of the drugs,  
as well as in experimental animals. Presently we have evaluated the  
inhibitory effects of potentized homeopathic preparations against N'- 
nitrosodiethylamine (NDEA) induced hepatocellular carcinoma in rats as  
well as 3-methylcholanthrene-induced sarcomas in mice. We have used  
Ruta, Hydrastis, Lycopodium and Thuja, which are commonly employed in  
homeopathy for treating cancer. Administration of NDEA in rats  
resulted in tumor induction in the liver and elevated marker enzymes  
such as gamma-glutamyl transpeptidase, glutamate pyruvate  
transaminase, glutamate oxaloacetate transaminase and alkaline  
phosphatase in the serum and in liver. Concomitant administration of  
homeopathic drugs retarded the tumor growth and significantly reduced  
the elevated marker enzymes level as revealed by morphological,  
biochemical and histopathological evaluation. Out of the four drugs  
studied, Ruta 200c showed maximum inhibition of liver tumor  
development. Ruta 200c and phosphorus 1M were found to reduce the  
incidence of 3-methylcholanthrene-induced sarcomas and also increase  
the life span of mice harboring the tumours. These studies demonstrate  
that homeopathic drugs, at ultra low doses, may be able to decrease  
tumor induction by carcinogen administration. At present we do not  
know the mechanisms of action of these drugs useful against  
carcinogenesis.

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