[Omeo33] Art 1086 - Homeopathy, 2010, 99 (1), 51-56

[Gino Santini]

Basophil models of homeopathy: a sceptical view
Madeleine Ennis

This paper examines the activation and inhibition of activation of  
human basophils. After a brief description of human basophils,  
different methods to determine basophil activation are discussed with  
a special emphasis on the use of flow cytometric methods, as these  
circumvent the potential problems of assays based on the loss of  
colour by activated basophils. The activation of human basophils by  
ultra-high dilutions of anti-IgE is discussed. The majority of the  
paper describes the inhibition of basophil activation by ultra-high  
dilutions of histamine. The results from published papers are  
described and discussed.
After over 20 years research trying to find out if high dilutions of  
histamine have a negative feedback effect on the activation of  
basophils by anti-IgE, what do we know? The methods are poorly  
standardized between laboratories – although the same is true for  
conventional studies. Certainly there appears to be some evidence for  
an effect – albeit small in some cases – with the high dilutions in  
several different laboratories using the flow cytometric  
methodologies. After standardization of a number of parameters, it is  
recommended that a multi-centre trial be performed to hopefully put an  
end to this “never-ending story”.

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