R: [Omeo33] Art 1044 - Pulm Pharmacol Ther, 2009, doi: 10.1016/j.pupt.2009.05.002

[Luigi Turinese]

Lo prendo io.

 

Luigi

 

  _____  

Da: omeopatia33-bounces a siomi.it [mailto:omeopatia33-bounces a siomi.it] Per
conto di Gino Santini
Inviato: giovedì 24 settembre 2009 15.42
A: omeopatia33 a siomi.it
Oggetto: [Omeo33] Art 1044 - Pulm Pharmacol Ther, 2009,doi:
10.1016/j.pupt.2009.05.002 

 

Low dose oral administration of cytokines for treatment of allergic asthma

Silvia Gariboldi, Marco Palazzo, Laura Zanobbio, Giuseppina F. Dusio,
Valentina Mauro, Umberto Solimene, Diego Cardani, Martina Mantovani and
Cristiano Rumio

 

Many inflammatory diseases are characterized by an imbalance among
lymphocyte populations, in particular Th1, Th2 and the recently described
Th17 cells. The Th1/Th2 imbalance is linked to many factors, but certainly
the role of cytokines is essential.

 

In Th2 diseases IL-4 expression is predominant, while Th1 pathologies are
characterized by high expression of IFN-γ and IL-12. Though today the
therapeutical proposal for many inflammatory diseases aims to re-establish
normal levels of Th1/Th2 cytokines, the pharmacological use of cytokines,
which are very active molecules, is limited by the possible collateral
effects. Therefore, our study aims to determine, in a murine model of
allergic asthma, the possible therapeutic activity of previous termlow dose
cytokines solutions, mechanically activated. We found that oral
administration of previous termlow doses IL-12 plus IFN-γ is able to solve
the bronchial hyperresponsiveness condition of mice, establishing normal
cytokine levels. The anti-asthma activity was confirmed by histological
analysis of lungs and broncho-alveolar lavage fluid cell count. Serum
ovalbumin-specific IgE was also significantly inhibited by treatment with
previous termlow dose activated cytokines solution. These findings may
suggest a novel approach to diseases which involve a Th1/Th2 imbalance.

 

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