[Omeo33] Art 1044 - Pulm Pharmacol Ther, 2009, doi: 10.1016/j.pupt.2009.05.002

[Gino Santini]

Low dose oral administration of cytokines for treatment of allergic  
asthma
Silvia Gariboldi, Marco Palazzo, Laura Zanobbio, Giuseppina F. Dusio,  
Valentina Mauro, Umberto Solimene, Diego Cardani, Martina Mantovani  
and Cristiano Rumio

Many inflammatory diseases are characterized by an imbalance among  
lymphocyte populations, in particular Th1, Th2 and the recently  
described Th17 cells. The Th1/Th2 imbalance is linked to many factors,  
but certainly the role of cytokines is essential.

In Th2 diseases IL-4 expression is predominant, while Th1 pathologies  
are characterized by high expression of IFN-γ and IL-12. Though today  
the therapeutical proposal for many inflammatory diseases aims to re- 
establish normal levels of Th1/Th2 cytokines, the pharmacological use  
of cytokines, which are very active molecules, is limited by the  
possible collateral effects. Therefore, our study aims to determine,  
in a murine model of allergic asthma, the possible therapeutic  
activity of previous termlow dose cytokines solutions, mechanically  
activated. We found that oral administration of previous termlow doses  
IL-12 plus IFN-γ is able to solve the bronchial hyperresponsiveness  
condition of mice, establishing normal cytokine levels. The anti- 
asthma activity was confirmed by histological analysis of lungs and  
broncho-alveolar lavage fluid cell count. Serum ovalbumin-specific IgE  
was also significantly inhibited by treatment with previous termlow  
dose activated cytokines solution. These findings may suggest a novel  
approach to diseases which involve a Th1/Th2 imbalance.

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