[Omeo33] Art 1243 - Pharmacognosy Mag, 2011, 27 (7), 234-242

[Gino Santini]

Circadian aspects of hyperthermia in mice induced by Aconitum napellus
Salvador Sánchez de la Peña, Robert B. Sothern, Fernando Santillán  
López, Irene Mendoza Lujambio, José Waizel-Bucay, Carolina Olarte  
Sánchez, Claudia Pérez Monroy, and Eduardo Tena Betancourt

Background - Aconitum napellus (Acn) is used topically to relieve  
pain, itching and inflammation, and internally to reduce febrile  
states, among others. Any circadian time-related consequences of Acn  
administration are unknown. The objective of this study was to explore  
the effects of two doses of Acn on body temperature (BT) of mice  
treated at six different times over 24 hours.
Materials and Methods - BALB/c female mice were housed in six chambers  
(six mice each) with air temperature 24 ± 3°C, humidity 60 ± 4%, and a  
12-hours light (L)/12-hours dark cycle, but with L-onset staggered by  
4 hours between chambers so that study at one external test time  
resulted in six test times (02, 06, 10, 14, 18 and 22 hours [h] after  
light onset). Rectal temperature (RT; in °C) was measured at baseline  
(B) and 1 hour after oral treatment with placebo (P) or two doses of  
Acn (6C and 30C, two studies each) in six studies over an 8 day span.  
The difference in RT for each mouse from the respective B + P  
timepoint mean RT was computed following each Acn treatment, and data  
from each of the six studies (original RT and difference from B + P)  
were analyzed for time-effect by analysis of variance (ANOVA) and for  
circadian rhythm by 24-hour cosine fitting.
Results - A circadian rhythm in RT was found at B and after P (mean:  
35.58°C vs. 35.69°C; peak: 15:31 h vs. 15:40 h) and after each Acn  
dose (30C or 6C). Acn induced hyperthermia and the overall change in  
BT was rhythmically significant for each dose (mean = +1.95°C vs.  
+1.70°C), with greatest hyperthermia observed during the L-span for  
each dose (peak = 08:56 h vs. 05:17 h).
Conclusion - Acn administered around the clock induced hyperthermia  
overall and in a time-dependent manner, with greatest effects during  
the resting (L) span. Thus, time of day may significantly impact the  
outcome of Acn and other homeopathic treatments and should be  
considered in determining optimal dosing and treatment time(s) in  
order to increase the desired outcome and decrease undesired effects.

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