[Omeo33] Art 1214 - Homeopathy, 2011, 100 (3), 148-156

[Gino Santini]

Rebound acid hypersecretion after withdrawal of gastric acid  
suppressing drugs: new evidence of similitude
Marcus Zulian Teixeira

Background - Homeopathy is based on the principle of similitude  
(similia similibus curentur) using medicines that cause effects  
similar to the symptoms of disease in order to stimulate the reaction  
of the organism. Such vital, homeostatic or paradoxical reaction of  
the organism is closely related to rebound effect of drugs.
Method - Review of the literature concerning the rebound effects of  
drugs used to suppress gastric acidity, particularly proton pump  
inhibitors (PPIs).
Results - The mechanism of action of these effects is discussed.  
Rebound in terms of clinical symptoms and physiological effects occur  
in about 40% of people taking PPIs, their timing depends on the half- 
life of the drug and the adaptation period of the physiological  
mechanisms involved. The wide use of PPIs may be linked to the rising  
incidence of carcinoid tumours.
Conclusions - These findings support Hahnemann’s concept of secondary  
action of drugs. We are developing a homeopathic materia medica and  
repertory of modern drugs on the basis of reported rebound effects.

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