[Omeo33] Art 0656 - Integrative Cancer Ther, 2006, 5 (4), 356-361

[Gino Santini]

Homeopathic Medicines Do Not Alter Growth and Gene Expression in  
Prostate and Breast Cancer Cells In Vitro
Rajesh L. Thangapazham, Anuj Sharma, Anoop K. Singh, John A. Ives,  
Radha K. Maheshwari, Wayne B. Jonas

Background: Homeopathy is an alternative medical system practiced in  
all parts of the world. Although several theories are proposed to  
explain the mechanisms of action, none are scientifically verified. In  
this study, the authors investigate the effect of selected homeopathic  
remedies often used to treat prostate and breast cancer. Materials and  
Methods: The authors investigated the effect of the homeopathic  
medicines Conium maculatum, Sabal serrulata, Thuja occidentalis,  
Asterias, Phytolacca, and Carcinosin on prostate and breast cancer  
cell (DU-145, LNCaP, MAT-LyLu, MDA-MB-231) growth and on gene  
expression that regulates apoptosis, using MTT and multiprobe  
ribonuclease protection assay. Results: None of the homeopathic  
remedies tested in different potencies produced significant inhibitory  
or growth-promoting activity in either prostate or breast cancer  
cells. Also, gene expression studies by ribonuclease protection assay  
produced no significant changes in mRNA levels of bax, bcl-2, bcl-x,  
caspase-1, caspase-2, caspase-3, Fas, or FasL after treatment with  
homeopathic medicines. Conclusions: The results demonstrate that the  
highly diluted homeopathic remedies used by homeopathic practitioners  
for cancer show no measurable effects on cell growth or gene  
expression in vitro using currently available methodologies.

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