[Omeo33] Art 1168 - Am J Inf Dis, 2010, 2 (6), 24-28

[Gino Santini]

Decreased Intensity of Japanese Encephalitis Virus Infection in Chick  
Chorioallantoic Membrane Under Influence of Ultradiluted Belladonna  
Extract
Bhaswati Bandyopadhyay, Satadal Das, Milan Sengupta, Chandan Saha,  
Kartick Chandra Das, Debabrata Sarkar and Chaturbhuj Nayak

Problem statement: No specific antiviral therapy is currently  
available despite an emergence and resurgence of Japanese encephalitis  
in South-East Asian Countries. There are only few recent studies,  
which were aimed to treat Japanese encephalitis with newer drugs.  
There is thus a real need for study on antiviral agents that can  
reduce the toll of death and neurological sequelae resulting from  
infection with this virus.
Approach: Optimum dilution of the JE virus was determined which could  
produce significant number of pocks on Chorioallantoic Membrane (CAM).  
Then ultradiluted belladonna preparations were used to see their  
inhibitory action on JE virus infection in CAM. Results: Ultradiluted  
belladonna showed significantly decreased pock count in CAM in  
comparison to JE virus control.
Conclusion: Ultradiluted belladonna could inhibit JE virus infection  
in CAM, which may be mediated through glycosidase inhibitory role of  
calystegines present in Belladonna.

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