[Omeo33] Art 1183 - Homeopathy, 2011, 100 (1), 36-61

[Gino Santini]

Biochemical and biological evidence of the activity of high potencies
W.E. Boyd M.A. and M. Brit

A method is described for investigating the possible action of  
microdoses of mercuric chloride on the hydrolysis of soluble starch  
with malt diastase.
The microdoses of the mercuric chloride used in the latest crucial  
series carried out in 1946, 1948, and 1952, were what are termed  
‘high potencies’ made in accordance with the pharmaceutical method  
of preparation of drags ordinarily used in the practice of  
homceotherapy.
These microdoses were prepared by separate stages of dilution, the  
solution at each stage being subjected to mechanical shock. The  
solutions were, theoretically, ‘dilutions’ of the order of 1 in  
10−61 and on present physical theory would not contain any molecules  
of the original mercuric chloride.
The difference in rate of hydrolysis between flasks containing starch,  
diastase, and distilled water (controls) and flasks containing starch,  
diastase and microdoses of mercuric chloride (tests) were compared  
colorimetrically by the Spekker absorptiometer, and the frequencies of  
the differences statistically analysed, as the results obtained showed  
biological scatter. More than 500 such comparisons were carried out.  
The differences of means were examined by the Fisher “t” test, the  
variances tested and Cochrane and Cox’s test applied where indicated.  
All the series gave a highly significant difference in the rate of  
hydrolysis between controls and tests, the microdoses stimulating the  
process. Statistically the significance is shown by the fact that a  
probability of <0.001 was obtained independently in each of the three  
years 1946, 1948 and 1952. The control results gave an approximately  
normal distribution.
The distribution, control methods, and accessory control procedures  
were considered to exclude, as a cause of the effects, adsorption of  
the original drug and the presence of extraneous contaminants by  
chance solely in test flasks. The only difference between control and  
microdose flasks was the addition of microdose, the distilled water  
being common to both controls and tests.
It was concluded that a factor, unidentified, derived from the  
mercuric chloride used, was present in solutions prepared by serial  
dilution with mechanical shock which could affect the distilled water  
diluent, that this change was transferable to subsequent ‘ultra- 
molecular’ stages of ‘dilution’, and that this factor was the  
source of the activity in the microdose solutions producing the  
acceleration of the rate of hydrolysis.
In an addendum there is described recent biological work which is also  
providing evidence of the presence of an active selective factor in  
‘high potencies’ derived from Strophanthus sarmentosus by the same  
methods of dilution with mechanical shock.

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