[Omeo33] Art 1157 - Homeopathy, 2010, 99 (4), 255-262

[Gino Santini]

Statins withdrawal, vascular complications, rebound effect and  
similitude
Marcus Zulian Teixeira

Hahnemann considered the secondary action of medicines to be a law of  
nature and reviewed the conditions under which it occurs. It is  
closely related to the rebound effects observed with many modern  
drugs. I review the evidence of the rebound effect of statins that  
support the similitude principle. In view of their indications in  
primary and secondary prevention of cardiovascular diseases, statins  
are widely prescribed. Besides reducing cholesterol biosynthesis, they  
provide vasculoprotective effects (pleiotropic effects), including  
improvement of endothelial function, increased nitric oxide  
bioavailability, antioxidant properties, inhibition of inflammatory  
and thrombogenic responses, stabilisation of atherosclerotic plaques,  
and others. Recent studies suggest that suspension of statin treatment  
leads to a rebound imparing of vascular function, and increasing  
morbidity and mortality in patients with vascular diseases. Similarly  
to other classes of modern palliative drugs, this rebound effect is  
the same as a secondary action or vital reaction described by Samuel  
Hahnemann, and used in homeopathy in a therapeutic sense.

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