[Omeo33] Art 0163 - Homeopathy, 2004, 93 (4), 173-178

[Gino Santini]

Rapid induction of protective tolerance to potential terrorist agents:  
a systematic review of low- and ultra-low dose research
A.L. Szeto, F. Rollwagen and W.B. Jonas

Objective: To systematically review the literature on the ability of  
low-dose (LD) and ultra-low-dose (ULD) toxin exposure to prevent and  
treat biological and chemical threats.
Methods: Laboratory research articles on protection or treatment from  
LD or ULD exposure for the 13 high-risk chemical and biological  
warfare threats were collected and systematically evaluated for  
quantity and scientific quality using pre-defined methodological  
criteria.
Results: Over 2600 articles were screened. Only five studies met the  
inclusion criteria examining stimulation and protective effects of LD-  
or ULD-exposures to the 13 pre-identified biological and chemical  
agents. The quality evaluation (QE) of these studies was above average  
with a mean QE score of 70.6% of maximum. Two articles of fair to good  
quality reported both protective and treatment efficacy from exposure  
of animals or humans to LD- and ULD-exposures to toxins of risk in  
biochemical warfare.
Conclusion: There is little research on agents of biological and  
chemical warfare investigating the possible use of LD- and ULD-toxins  
for protection and treatment. The existing literature is generally of  
good quality and indicates that rapid induction of protective  
tolerance is a feasible but under-investigated approach to  
bioterrorist or biowarfare defense. In our opinion, further research  
into the role of induced protection with LD- and ULD-toxic agents is  
needed.

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