[Omeo33] Art 0995 - Homeopathy, 2009, 98 (2), 83-87

[Simonetta Bernardini]

questo bel lavoro di ormesi lo prendo io..

simonetta 
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  From: Gino Santini 
  To: omeopatia33 a siomi.it 
  Sent: Saturday, January 16, 2010 9:23 AM
  Subject: [Omeo33] Art 0995 - Homeopathy, 2009, 98 (2), 83-87


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  Isopathic versus enantiomeric inhibition of U-50488 HCl toxicity â?" experimental studies
  R.M. Kuzeff, M. Topashka-Ancheva and R. Metcheva


  Background - Previous studies have investigated toxicity inhibition of optically active compounds by potentized preparations of their enantiomers. It was hypothesised that inhibition of toxicity may be stereospecific. This paper presents 2 studies investigating stereoisomer potencies in terms of their ability to counteract toxicity of the (â^') stereoisomer. The stereoisomers used were (â^')-trans-(1S,2S)-U-50488 HCl and (+)-trans-(1R,2R)-U-50488 HCl.
  Materials & methods - Designs were prospective, blind, randomised, intention-to-treat and compared the efficacy of 2 indistinguishable treatments. The outcome was the difference in survival. Potency â?~chordsâ?T consisting of 4th, 12th and 30th approximately centesimal dilutions were prepared, representing concentrations of 1.08 Ã- 10â^'10 M. One study compared inhibition of (â^')-U-50488 toxicity injected ip at the estimated LD50 into male ICR mice, treated with a potency chord of the same stereoisomer, with control (â?~isopathicâ?T study). The other study compared inhibition of toxicity by potency chords made from the stereoisomers (+)-U-50488 and (â^')-U-50488 (â?~enantiomerâ?T study), Treatments were administered orally on 11 occasions: twice before and nine times after ip injections.
  Results - The isopathic study did not yield a significant result. In the enantiomer study, comparison of isopathy with enantiomer potency treatment showed a highly significant difference odds ratio 1.97 (95% CI: 1.23â?"3.14).
  Conclusion - We conclude that enantiomeric potencies are superior to identically produced isopathic potencies, in inhibiting toxicity of (â^')-U-50488 HCl. Homeopathic inhibition of toxicity may be stereospecific.


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