[Omeo33] Art 1055 - JACM, 2009, 15 (10), 1121-1126

[Gino Santini]

In Vitro Examination of Potentized Atropine Sulfate Dilutions on the  
Contractility of the Isolated Rat Ileum
Christiane Siegling-Vlitakis, Holger Martens, Rainer Lüdtke

Objectives: Atropine sulphate, a competitive antagonist of  
acetylcholine (ACh) at muscarinic receptors, was first isolated from  
Atropa belladonna, one of the most used and best known homeopathic  
medicines. It has been suggested that high potencies of homeopathic  
atropine sulphate might have an influence on ACh-induced contraction  
of smooth muscles. The aim of the study was to determine the effects  
of homeopathic dilutions of atropine sulphate D6, D32, and D100  
compared to the potentized diluents L6, L32, and L100 on ACh-induced  
contraction of isolated rat ileum.
Design: Forty-eight (48) ileal sections from 12 male Wistar rats were  
incubated in modified Krebs solutions, and the contractile activity  
responses to ACh obtained in the absence and presence of the test  
substances were recorded. Investigators and biometrician were  
completely blinded.
Results: No significant effects of atropine sulphate D6, D32, or D100  
could be found (all p>0.4 after Bonferoni-Holm correction) compared to  
the potentized diluents L6, L32, and L100, respectively. These figures  
did not change considerably even when strict a priori criteria were  
applied that define a measurement as valid and comparable.
Conclusions: Our experiments could not replicate previous results on  
the effects of homeopathic atropine.

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