[Omeo33] Art 0807 - JACM, 2005, 11 (1), 21-27

[Gino Santini]

Homeopathy for Menopausal Symptoms in Breast Cancer Survivors: A  
Preliminary Randomized Controlled Trial
Jacobs, Herman, Heron, Olsen and Vaughters

Objectives: To carry out a preliminary trial evaluating the  
effectiveness of two types of homeopathy for the treatment of  
menopausal symptoms in breast cancer survivors.
Design: Randomized, double-blinded, placebo-controlled
Settings/location: Private medical clinic, Seattle, WA.
Subjects: Women with a history of breast cancer who had completed all  
surgery, chemotherapy, and radiation treatment and who had an average  
of at least three hot flashes per day for the previous month.
Interventions: Subjects were randomized to receive either an  
individualized homeopathic single remedy, a homeopathic combination  
medicine, or placebo. Patients were seen by homeopathic providers  
every 2 months for 1 year.
Outcome measures: Hot flash frequency and severity, Kupperman  
Menopausal Index (KMI), Short Form 36 (SF-36).
Results: There was no significant difference found in the primary  
outcome measure, the hot flash severity score, although there was a  
positive trend in the single remedy group during the first 3 months of  
the study (p = 0.1). A statistically significant improvement in  
general health score in both homeopathy groups (p < 0.05) on the SF-36  
after 1 year was found. Evidence of a homeopathic "drug proving" in  
the subjects receiving the homeopathic combination medicine who were  
not taking tamoxifen also was found.
Conclusions: Small sample size precludes definitive answers, but  
results from this preliminary trial suggest that homeopathy may be of  
value in the treatment of menopausal symptoms and improving quality of  
life, especially in those women not on tamoxifen. Larger studies  
should be carried out that also include healthy women who want to  
avoid hormone replacement therapy.

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