[Omeo33] Art 1109 - JACM, 2010, 16 (4), 347-355

[Gino Santini]

Homeopathic Treatment of Patients with Migraine: A Prospective  
Observational Study with a 2-Year Follow-Up Period
Claudia M. Witt, Rainer Lüdtke, Stefan N. Willich

Objectives and background: The objective of this study was to evaluate  
treatment details and possible effects of an individualized  
homeopathic treatment in patients with migraine in usual care.
Design: This was a prospective multicenter observational study.  
Consecutive patients beginning homeopathic treatment in primary care  
practices were evaluated over 2 years using standardized  
questionnaires. The data recorded included diagnoses (International  
Classification of Diseases, Ninth Revision) and current complaints,  
including their severity (numeric rating scale=0–10), health-related  
quality of life (QoL, 36-item Short-Form Health Survey), medical  
history, consultations, homeopathic and conventional treatments, as  
well as other health service use.
Results: Two hundred and twelve (212) adults (89.2% women), mean age  
39.4±10.7 years were treated by 67 physicians. Patients had suffered  
from migraine for a period of 15.2±10.9 years. Most patients (90.0%)  
were conventionally pretreated. The physician workload included taking  
the initial patient history (120±45 minutes), case analysis (40±47  
minutes), and follow-ups (7.3±7.0, totaling 165.6±118.8 minutes).  
Patients received 6.2±4.6 homeopathic prescriptions. Migraine severity  
showed marked improvement with a large effect size (Cohen's d=1.48  
after 3 months and 2.28 after 24 months. QoL improved accordingly  
(Mental Component Score and Physical Component Score after 24 months:  
0.42 and 0.45). The use of conventional treatment and health services  
decreased markedly.
Conclusions: In this observational study, patients seeking homeopathic  
treatment for migraine showed relevant improvements that persisted for  
the observed 24 month period. Due to the design of this study,  
however, it does not answer the question as to whether the effects are  
treatment specific or not.

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