[Omeo33] Art 0743 - Asian Pac J Cancer Prev, 2007, 8 (1), 98-102
Gino Santini
g.santini a ismo.it
Ven 9 Apr 2010 09:03:32 CEST
Inhibition of chemically induced carcinogenesis by drugs used in
homeopathic medicine
Kumar KH, Sunila ES, Kuttan G, Preethi KC, Venugopal CN, Kuttan R.
Homeopathy is considered as one modality for cancer therapy. However,
there are only very few clinical reports on the activity of the drugs,
as well as in experimental animals. Presently we have evaluated the
inhibitory effects of potentized homeopathic preparations against N'-
nitrosodiethylamine (NDEA) induced hepatocellular carcinoma in rats as
well as 3-methylcholanthrene-induced sarcomas in mice. We have used
Ruta, Hydrastis, Lycopodium and Thuja, which are commonly employed in
homeopathy for treating cancer. Administration of NDEA in rats
resulted in tumor induction in the liver and elevated marker enzymes
such as gamma-glutamyl transpeptidase, glutamate pyruvate
transaminase, glutamate oxaloacetate transaminase and alkaline
phosphatase in the serum and in liver. Concomitant administration of
homeopathic drugs retarded the tumor growth and significantly reduced
the elevated marker enzymes level as revealed by morphological,
biochemical and histopathological evaluation. Out of the four drugs
studied, Ruta 200c showed maximum inhibition of liver tumor
development. Ruta 200c and phosphorus 1M were found to reduce the
incidence of 3-methylcholanthrene-induced sarcomas and also increase
the life span of mice harboring the tumours. These studies demonstrate
that homeopathic drugs, at ultra low doses, may be able to decrease
tumor induction by carcinogen administration. At present we do not
know the mechanisms of action of these drugs useful against
carcinogenesis.
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