[Omeo33] Art 1049 - eCAM, 2009, doi: 10.1093/ecam/nem067

[Gino Santini]

Amelioration of Carcinogen-Induced Toxicity in Mice by Administration  
of a Potentized Homeopathic Drug, Natrum Sulphuricum 200
Nandini Bhattacharjee, Surajit Pathak and Anisur Rahman Khuda-Bukhsh

To examine if a potentized homeopathic drug, Natrum Sulphuricum 200  
(Nat Sulph-200) has protective potentials against  
hepatocarcinogenesis, liver tumors were induced in mice through  
chronic feeding of P-dimethylaminoazobenzene (p-DAB; initiator of  
hepatocarcinogenesis) and phenobarbital (PB; promoter). Mice were  
divided into five sub-groups: fed normal low protein diet (Gr. I,  
normal control); fed normal low protein plus alcohol-200 (vehicle of  
the homeopathic remedy) (Gr. II); fed diet mixed with 0.06% p-DAB plus  
0.05% PB (Gr. III); fed diet and carcinogens like Gr.III, plus alcohol  
200 (positive control for drug fed mice) (Gr. IV) and fed diet and  
carcinogens like Gr. III, plus Natrum Sulphuiricum-200 (Gr. V; drug  
fed). Mice were sacrificed at day 7, 15, 30, 60, 90 and day 120 for  
study of cytogenetical endpoints like chromosome aberrations (CA),  
micronuclei (MN), mitotic index (MI) and sperm head anomaly (SHA) and  
biochemical toxicity parameters like aspartate amino transferase  
(AST), alanine amino transferase (ALT), acid (AcP) and alkaline (AlkP)  
phosphatases, lipid peroxidation (LPO) and reduced glutathione (GSH)  
content. Less number of liver tumors were observed in Gr. V (drug fed)  
mice. Administration of Nat Sulph 200 reduced genomic damage,  
activities of AcP, AlkP, AST, ALT, LPO and increased GSH content.  
Therefore, independent replication of the study by others is encouraged.

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