[Omeo33] Art 0615 - Homeopathy, 2006, 95 (4), 215-222

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Lo perndo, mi mandi il full?
Francesco
  ----- Original Message ----- 
  From: Gino Santini 
  To: omeopatia33 a siomi.it 
  Sent: Wednesday, October 14, 2009 5:37 PM
  Subject: [Omeo33] Art 0615 - Homeopathy, 2006, 95 (4), 215-222


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  Evaluation of specific and non-specific effects in homeopathy: Feasibility study for a randomised trial
  Peter Fisher, Rob McCarney, Christian Hasford and Andrew Vickers


  Objective - To determine the feasibility, in terms of acceptability to patients, physicians and other staff; data return and statistical power of a study to elucidate the relative contributions of specific and non-specific effects in homeopathic treatment of dermatitis. Design - Randomised, controlled 4-arm trial, 2 arms double-blind. Setting - Outpatient clinic, Royal London Homoeopathic Hospital. Participants - Seventy-five adult patients with dermatitis. Interventions - Patients were randomly allocated to: 'fast track' open verum homeopathy, 'fast track' double-blind verum homeopathy, 'fast track' double-blind placebo homeopathy or waiting list control. Main outcome measures - One hundred millimeter visual analogue scale of overall symptom severity; 10 point digital scores of sleep, itching, skin condition; weekly 5-point Likert scale of topical steroid use; Dermatology Life Quality Index at entry and completion. Results - Recruitment was below target, but the study was acceptable to staff and feasible. Blinded patients were more likely to withdraw (P=0.021, É'2 test). After correction for baseline differences and multiple comparisons, no outcome measure showed statistically significant between group differences. Blindness appeared to have a negative effect, but this was confounded by differential withdrawal. Conclusions - A definitive trial of this design is unlikely to discriminate the relative contributions of the non-specific and specific effects to the outcome of homeopathic treatment of dermatitis, because of patient preference issues.


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