[Omeo33] Art 1064 - eCAM, 2009, doi: 10.1093/ecam/nen090

[Gino Santini]

Evidences of Protective Potentials of Microdoses of Ultra-high Diluted  
Arsenic Trioxide in Mice Receiving Repeated Injections of Arsenic  
Trioxide
Pathikrit Banerjee, Soumya Sundar Bhattacharyya, Surajit Pathak,  
Naoual Boujedaini, Philippe Belon and Anisur Rahman Khuda-Bukhsh

The present study was undertaken to examine if microdoses of ultra- 
high diluted arsenic trioxide (a potentized homeopathic remedy,  
Arsenicum Album 200C, diluted 10–400 times) have hepatoprotective  
potentials in mice subjected to repeated injections of arsenic  
trioxide. Arsenic intoxicated mice were divided into: (i) those  
receiving Arsenicum Album-200C daily, (ii) those receiving the same  
dose of diluted succussed alcohol (Alc 200C) and (iii) another group  
receiving neither drug nor succussed alcohol. Two other control groups  
were also maintained: one fed normal diet only and the other receiving  
normal diet and Alc-200C. Toxicity biomarkers like aspartate and  
alanine aminotransferases, glutathione reductase, catalase, succinate  
dehydrogenase, superoxide dismutase and reduced glutathione contents  
were periodically assayed keeping the observer ‘blinded’.  
Additionally, electron microscopic studies and gelatin zymography for  
matrix metalloproteinases of liver tissues were made at day 90 and  
120. Blood glucose, hemoglobin, estradiol and testosterone contents  
were also studied. Compared to controls, Arsenicum Album-200C fed mice  
showed positive modulations of all parameters studied, thereby  
providing evidence of protective potentials of the homeopathic drug  
against chronic arsenic poisoning.

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