[Omeo33] Art 0988 - EMBO Rep, 2009, 10 (3), 194-200

[Gino Santini]

Natural products and drug discovery. Can thousands of years of ancient  
medical knowledge lead us to new and powerful drug combinations in the  
fight against cancer and dementia?
Hong-Fang Ji, Xue-Juan Li & Hong-Yu Zhang

The medicinal use of natural products—compounds that are derived from  
natural sources such as plants, animals or micro-organisms—precedes  
recorded human history probably by thousands of years.  
Palaeoanthropological studies at the cave site of Shanidar, located in  
the Zagros Mountains of Kurdistan in Iraq, have suggested that more  
than 60,000 years ago, Neanderthals might have been aware of the  
medicinal properties of various plants, as evidenced by pollen  
deposits in one of the graves at the site (Solecki, 1975). Over the  
ensuing millennia, humankind discovered and made use of an enormous  
range of natural compounds; the latest version of the Dictionary of  
Natural Products (DNP; http://dnp.chemnetbase.com) has just over  
214,000 entries.

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