[Omeo33] Art 1000 - Homeopathy, 2009, 98 (2), 114-121

[Gino Santini]

Antidepressants, suicidality and rebound effect: evidence of similitude?
Marcus Zulian Teixeira

Samuel Hahnemann noticed that palliative treatments for the symptoms  
of chronic diseases, after an initial improvement, provoked symptoms  
similar but stronger symptoms to those initially suppressed. He  
regarded this as a consequence of the vital reaction of the organism:  
an automatic and instinctive capacity to return to the initial health  
condition altered by medicines. Using this homeostatic conception of  
the organism as a treatment rationale, Hahnemann proposed the therapy  
of similarity, administering to the patients medicines capable of  
causing, in healthy individuals, similar symptoms to the natural  
disease. Based on experimental observations, he proposed that the  
primary action of the drug was followed by the secondary and opposite  
action of the organism, inaugurating homeopathic pharmacology, and  
alerting to the harmful consequences of palliative medicines in  
susceptible individuals. Such iatrogenic events can be observed in  
contemporary medicine, after the withdrawal of modern enantiopathic  
medicines, according to the study of the rebound effect or paradoxical  
reaction of the organism. Method:This study reviews the recent studies  
which describe suicidality after the suspension or discontinuation of  
second generation antidepressants according to the hypothesis of the  
paradoxical reaction of the organism. Conclusions: Rebound and  
withdrawal effects, including suicidality occur with antidepressant  
drugs. They are relatively rare but more intense than the primary  
action of the drug. The probability of such effects is influenced by  
patient factors including age and diagnosis, and drug factors  
including half-life.

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