[Omeo33] Art 0996 - Homeopathy, 2009, 98 (2), 88-91

[Gino Santini]

Dual effect of Toxicodendron pubescens on Carrageenan induced paw  
edema in rats
Chandragouda R. Patil, Ajit R. Gadekar, Pramit N. Patel, Ashish  
Rambhade1, Sanjay J. Surana and Mahendra H. Gaushal

Background - Toxicodendron pubescens is the current botanical name of  
homeopathic Rhus toxicodendron (Rhus tox). Rhus tox drug is widely  
used in homeopathically diluted form in the treatment of inflammatory  
and edematous conditions. We studied the effect of crude form of this  
plant, after single and multiple doses in Carrageenan induced paw  
inflammation in rats.
Method - We evaluated effects of single dose and multiple doses of  
orally administered Rhus tox on Carrageenan induced paw inflammation  
in rats. We tested 10 mg/kg, 20 mg/kg and 40 mg/kg doses of Rhus tox.  
In the single dose study, Rhus tox was administered 1 h prior to the  
subplantar injection of Carrageenan. In the multiple dose study, Rhus  
tox was administered twice daily for three days and Carrageenan was  
injected 1 h after the last dose. Paw volume was measured using a  
digital plethysmometer.
Results - Administration of a single dose of Rhus tox 1 h prior to  
injection of Carrageenan significantly reduced the paw inflammation in  
a dose dependent manner. Administration of multiple doses of Rhus tox  
increased the intensity of inflammation induced by Carrageenan, but  
this was not statistically significant.
Conclusion - Rhus tox, in crude form, exerts anti-inflammatory effects  
after a single dose and proinflammatory effect after multiple doses in  
Carrageenan induced paw inflammation in rats. Further study is needed  
to explain this dual effect.

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