[Omeo33] Art 0997 - Homeopathy, 2009, 98 (2), 92-96

[Gino Santini]

Homeopathic treatment for bone regeneration: experimental study
Janete Dias Almeida, Emília Angela Loschiavo Arisawa, Ivan Balducci,  
Rosilene Fernandes da Rocha1 and Yasmin Rodarte Carvalho

Aim and method - The objective of this research was to study the  
effect of homeopathic treatment with Plumbum metallicum (Plumbum met.)  
on mandibular bone repair in rats.
Materials and methods - We analyzed the mandibles of 60 male rats,  
approximately 3-month-old, randomly divided into three groups of 20  
animals each: control, treated with calcitonin, and treated with a  
homeopathic medicine. A circumscribed bone defect measuring 4 mm in  
diameter was made in the mandible and covered with a  
polytetrafluorethylene (PTFE) barrier. The group treated with  
calcitonin received 2 IU/kg intramuscularly three times a week; the  
group treated with Plumbum met. 30c received three drops in water  
every day. The animals were sacrificed after 7, 14, 21 and 28 days.  
The mandibles were removed and submitted to histologic and  
histomorphometric analyses.
Results - Data were analyzed statistically by two-way ANOVA and by the  
Tukey test. The interaction effect (ANOVA, F df(6; 48) = 4.64; p =  
0.001 < 0.05) indicated that the relationship between treatments was  
not the same at each time of sacrifice. Although statistical analysis  
of the histomorphometric data showed a similar results for the treated  
and control groups. But histological analysis showed complete filling  
of the surgical defect throughout its extent was only for the group  
treated with Plumbum met.
Conclusion - The study demonstrated that for repair of surgical  
defects in rat mandibles Plumbum met. 30c and control did not differ  
significantly in histomorphometric terms.

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