[Omeo33] Art 0948 - Homeopathy, 2008, 97 (3), 141-144
Gino Santini
g.santini a ismo.it
Gio 23 Lug 2009 08:15:14 CEST
An animal model for the study of Chamomilla in stress and depression:
pilot study
Sandra Augusta Gordinho Pinto, Elisabeth Bohland, Cideli de Paula
Coelho, Maria Sílvia Furquim de Azevedo Morgulis and Leoni Villano
Bonamin
The behavioral and hematological effects of treatment with Chamomilla
6cH in mice subjected to experimental stress are described. Swiss mice
were randomly divided into pairs, one animal was inoculated with
Ehrlich's tumor, the other was treated daily with Chamomilla 6cH or
control or received no treatment. After 7 days, the animals were
observed in an open-field arena and blood samples taken. Mice who
cohabitated with a sick cage-mate showed a decrease in their general
activity, but those treated with Chamomilla 6cH were less severely
affected (p = 0.0426). No hematological changes were observed.
In a second experiment, the forced swimming test was applied to mice
pre-treated with Chamomilla 6cH, controls were: water, 10% ethanol or
amitriptyline. Only the amitriptyline and ethanol treated groups
showed significant excitatory behavior (p = 0.0020), Chamomilla 6cH
treated animals' scores intermediate between water control and ethanol
or amitriptyline. A decrease in the leukocyte count was observed in
the amitriptyline and Chamomilla 6cH treated groups (p = 0.039). These
data suggest that treatment with Chamomilla 6cH is related to the
recovery of basal behavioral conditions in mice subjected to stressful
conditions.
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