[Omeo33] Art 1010 - eCAM, 2009

[Gino Santini]

Modulation of Signal Proteins: A Plausible Mechanism to Explain How a  
Potentized Drug Secale Cor 30C Diluted beyond Avogadro's Limit Combats  
Skin Papilloma in Mice
Anisur Rahman Khuda-Bukhsh, Soumya Sundar Bhattacharyya, Saili Paul,  
Suman Dutta, Naoual Boujedaini and Philippe Belon


In homeopathy, ability of ultra-high diluted drugs at or above potency  
12C (diluted beyond Avogadro's limit) in ameliorating/curing various  
diseases is often questioned, particularly because the mechanism of  
action is not precisely known. We tested the hypothesis if suitable  
modulations of signal proteins could be one of the possible pathways  
of action of a highly diluted homeopathic drug, Secale cornutum 30C  
(diluted 1060 times; Sec cor 30). It could successfully combat DMBA +  
croton oil-induced skin papilloma in mice as evidenced by  
histological, cytogenetical, immunofluorescence, ELISA and immunoblot  
findings. Critical analysis of several signal proteins like AhR, PCNA,  
Akt, Bcl-2, Bcl-xL, NF-kB and IL-6 and of pro-apoptotic proteins like  
cytochrome c, Bax, Bad, Apaf, caspase-3 and -9 revealed that Sec cor  
30 suitably modulated their expression levels along with amelioration  
of skin papilloma. FACS data also suggested an increase of cell  
population at S and G2 phases and decrease in sub-G1 and G1 phages in  
carcinogen-treated drug-unfed mice, but these were found to be near  
normal in the Sec cor 30-fed mice. There was reduction in genotoxic  
and DNA damages in bone marrow cells of Sec Cor 30-fed mice, as  
revealed from cytogenetic and Comet assays. Changes in histological  
features of skin papilloma were noted. Immunofluorescence studies of  
AhR and PCNA also suggested reduced expression of these proteins in  
Sec cor 30-fed mice, thereby showing its anti-cancer potentials  
against skin papilloma. Furthermore, this study also supports the  
hypothesis that potentized homeopathic drugs act at gene regulatory  
level.

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