[Omeo33] Art 0995 - Homeopathy, 2009, 98 (2), 83-87

[Gino Santini]

Isopathic versus enantiomeric inhibition of U-50488 HCl toxicity –  
experimental studies
R.M. Kuzeff, M. Topashka-Ancheva and R. Metcheva

Background - Previous studies have investigated toxicity inhibition of  
optically active compounds by potentized preparations of their  
enantiomers. It was hypothesised that inhibition of toxicity may be  
stereospecific. This paper presents 2 studies investigating  
stereoisomer potencies in terms of their ability to counteract  
toxicity of the (−) stereoisomer. The stereoisomers used were (−)- 
trans-(1S,2S)-U-50488 HCl and (+)-trans-(1R,2R)-U-50488 HCl.
Materials & methods - Designs were prospective, blind, randomised,  
intention-to-treat and compared the efficacy of 2 indistinguishable  
treatments. The outcome was the difference in survival. Potency  
‘chords’ consisting of 4th, 12th and 30th approximately centesimal  
dilutions were prepared, representing concentrations of 1.08 × 10−10  
M. One study compared inhibition of (−)-U-50488 toxicity injected ip  
at the estimated LD50 into male ICR mice, treated with a potency chord  
of the same stereoisomer, with control (‘isopathic’ study). The  
other study compared inhibition of toxicity by potency chords made  
from the stereoisomers (+)-U-50488 and (−)-U-50488 (‘enantiomer’  
study), Treatments were administered orally on 11 occasions: twice  
before and nine times after ip injections.
Results - The isopathic study did not yield a significant result. In  
the enantiomer study, comparison of isopathy with enantiomer potency  
treatment showed a highly significant difference odds ratio 1.97 (95%  
CI: 1.23–3.14).
Conclusion - We conclude that enantiomeric potencies are superior to  
identically produced isopathic potencies, in inhibiting toxicity of  
(−)-U-50488 HCl. Homeopathic inhibition of toxicity may be  
stereospecific.

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