[Omeo33] Art 0853 - Br J Oral Maxillofacial Surgery, 1984, 22 (1), 42-49

[Gino Santini]

Metronidazole (flagyl) and arnica montana in the prevention of 
post-surgical complications, a comparative placebo controlled 
clinical trial
GSN Kazyro

A double blind trial, was designed, in which 118 patients undergoing 
the removal of impacted wisdom teeth were randomly divided into the 
following groups; 41 patients received Metronidazole, 39 patients 
received Arnica Montana, 38 patients received the placebo. 
Metronidazole was more effective in pain control than Arnica 
(p<0.001) and placebo (p<0.01). It prevented swelling better than 
Arnica (p<0.01) and placebo (p<0.05) and was more effective in 
promoting healing than Arnica (p<0.01) and placebo (p<0.01), but had 
no effect on trismus when compared with Arnica (p>0.1) and placebo 
(p>0.02). Arnica Montana appeared to give rise to greater pain than 
placebo (p<0.05) and caused more swelling than the placebo (p<0.01).

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